Guide Controversies in Treating Diabetes: Clinical and Research Aspects (Contemporary Endocrinology)

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  2. Controversies in Treating Diabetes - Clinical and Research Aspects | Derek Leroith | Springer
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The Hypoglucemic Effect of the Antioxidant Drug. Nina M. Musurlieva and Mariya S. Sudesh S. Raju and Vinayak Kumar. Self-Care among Diabetic Amputee. David Berbrayer. Magnesium and Type 2 Diabetes: An Update. Ljiljana M Jowitt. Manmohan K. Kamboj, Kathryn J. Stephens, Richard J. Brilli, Heather L.

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Yardley, Jeff Lewis, Richard E. McClead, Jr. Anders Thelin and Sara Holmberg.

Poovazhagi Varadarajan and Saradha suresh. Wenyi Wu and Luosheng Tang. Pizarro-Delgado and J. Recent Advances in Insulin Therapy for Diabetes. Novel Insulin Receptor-Signaling Platform. Masayoshi Yamaguchi. A Developing Country Perspective. Kameel Mungrue and Verna Farrell-Williams. All articles are fully peer reviewed, free to access and can be downloaded from our ClinMed archive.

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Controversies in Treating Diabetes - Clinical and Research Aspects | Derek Leroith | Springer

Concentrated insulin are a way forward for patients who needs higher units of insulin especially Human insulin which address the issues of higher cost and the need for higher concentration in the same or lesser volume of insulin. However, data on hour glycemic control with concentrated insulin in In The event was conducted in the afternoon over 3 hours with refreshments being offered Seronegative cases are said to be more common among black Africans.

The aim of this study was to find out the prdevalence of pancreatic autoantibodies among multiethnic group of newly diagnosed Sudanese children by testing for multiple antibodies and to see how common are seronegative cases as reported in black A Microalbuminuria is the first clinical sign of renal dysfunction in patients with diabetes mellitus. A urine total protein: creatinine ratio TPCR is a convenient and inexpensive measure of proteinuria and could be used to predict the presence of microalbuminuria in diabetic patients.

The aim of this study was to assess the prevalence and associated risk factors of proteinuria among type-2 diabetic p The positive control grou Among top ten diseases in in Saudi Arabia, chronic kidney disease was the 4th common cause of most of the deaths in the kingdom. Hence, the study aimed at determining the major concomitant chronic disorders and their association with kidney diseases in Hail region.

To estimate retrospectively the prevalence of hypothyroidism in patients with MetS in Saudi community based hospital. We analyzed retrospectively participants whom are between the age 18 to years. The present retrospective study was conducted to find out the association of serum thyroid stimulating hormone TSH and free thyroxine FT4 with urinary albumin excretion in euthyroid subjects with type 2 diabetes mellitus T2DM in Saudi community based hospital.

Type 1 Diabetes Mellitus - Concerns and Care

We analyzed retrospectively participants whom are between the age 20 to 96 years. All patients were from the popu The care of patients with diabetes mellitus is multidisciplinary and involves a number of healthcare personnel. Effective communication between diabetic patients and healthcare personnel influence self-management and health outcomes. The study evaluated the diabetic patient's assessment of the communication skills of the healthcare providers, as well as a Most commonly the pain is thought to be secondary to diabetic neuropathy. It becomes even more problematic if there is significant weight loss, if extensive investigations have not found any organic pathology and if the pain does not fit into any pattern of diabetic neuropathy.

We present such a case where a young years-old female diabetic had lost At the clinic individuals were screened for type II DM and depending on the outcome, a specific pathway was designed for them to follow ensuring patients and their families remained on the correct health initiative. A cross-sectional study design was used to study adult Qatari nationals registered at Al Wakra Health center's Smart Clinic using data obtained between Jan Jan The s However, it is little known about role of therapeutic insulin administration on dissemination of infectious diseases in people with diabetes mellitus.

The study included the clinically isolated strains of Escherichia coli E.

Early diagnosis and evaluation of these conditions of DM pa-tients are important to maintain the quality of life of the patients. Therefore in conditions with insulin resistance the impairment of g Thus, the present study was under taken to evaluate the effect of zinc supplementation on zinc status and carbohydrate metabolism in non-diabetic and diabetic rats fed high-calcium diet.

Diabetes is a group of metabolic disorders characterized by chronic hyperglycemia resulting from disorders of secretion or the action of insulin. This hyperglycemia is a One of the recurring themes of these guidelines is education, education, education. This is essential for self-management by patients with diabetes and also for the safety and effectiveness of the care they Participants in both groups were required to take either IU or IU of From a physiological perspective, glucose is the primary metabolic fuel for cells.

However, many neurodegenerative disorders have been recently associated with impaired glucose transport and metabolism and with mitochondrial dysfunction causing energy deficits, such as in Alzheimer's disease, Parkinson's disease, general The rapid increasing prevalence, high morbidity and mortality of the disease must be encountered by an increase in scientific research.

Animal models are very important in the preclinical studies to validate the use of new drugs. However, there is limited insight into function of these chemokines as well as the potential role of insulin in the modulation of these chemokines. We tested the hypothesis that insulin alters these chemokines by measuring changes in their circulating levels in response to elevated insulin in a group The increased nitrative stress and peroxynitrite, activation of iNOS and TGF-B1 play a crucial role in the pathogenesis of diabetic cardiomyopathy.

Until recently, pyomyositis was considered uncommon in the temperate zone. Currently there is an increase in the number of cases of pyomyositis in temperate climates Patients with low health literacy worsen the glycaemic control and diabetes complications. However, lack of studies on the effect of health literacy that affects clinical health outcomes and the effect of health education on it The current options for the treatment of the classic risk factors such as dyslipoproteinemia, hypertension, and diabetes have so far not been able to alter this situation to a fundamental extent, meaning that new therapeutic approaches must be identified It is estimated to reach million by ; of which the majority are diagnosed with type 2 diabetes T2DM.

Sri Lanka is one of the countries with the highest diabetes prevalence rates in the world.


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There were 1. Each group was matched for age, gender, body mass index BMI and in the case of the diabetic controls duration of diabetes. Microalbumin, urinary amylase, glycosylated hemoglobin HbA1c and blood pressure were measured using standard techniques Previous studies, however, have not found a direct association between the enzyme phenotype and susceptibility to the disease but have only found associations with its clinical manifestations A common underpinning that exists behind the mechanisms of insulin resistance is the overproduction of reactive oxygen species, which may be exacerbated by a protein target known as thioredoxin-interacting protein TXNIP.

A Quantitative Study in Type-2 Diabetes Patients Ezequiel Pinto, Nidia Braz, Tania Nascimento and Eurico Gomes Article Type: Original Research First Published: December 28, Type 2 diabetes patients' adherence to pharmacotherapy is higher than adherence to nutritional therapy or lifestyle change behaviours, and patients do not value nutritional therapy in the same level as they value other types of interventions Metformin is available as a standard, immediate-release formulation usually taken two or three times daily and also in Extended-Release XR formulations designed to be taken once-daily Local microenvironment of islets includes their immediate extracellular matrix and other molecules that surround islets within the exocrine pancreas.

Transplantation of pancreatic islets, which is a promising method for treatment of type 1 diabetes Subjects received a wireless glucose monitor with the capability to transmit their glucose measurements to an external server via cellular service. The clinician analyzed these measurements, and communicated with the patient via the glucometer Participants who were free from known cardiac disease or severe orthopedic problems referred to an exercise specialist for a fitness assessment Patient is a year-old Jamaican male with history of uncontrolled, insulin requiring Type 2 diabetes mellitus.

He presented with new onset of hypoglycemia and improvement in hemoglobin A1C without any changes in diabetes regimen Worldwide, the number of people aged 60 or older is growing faster than all younger age groups, with most of the increase in developing countries We compared the indices for the quality of glycemic control and determined their relationship with glucose profile complexity Solomon Habtemariam Article Type: Letter to Editor First Published: May 20, For thousands of years, mankind has used plants as a source of medicine either in their crude mixture forms or purified single chemical entities.

While the use of crude plant extracts in prescription drugs today is extremely rare, we still have a significant number of our drug therapies tracing their origin back to natural products. In principle, drug therapeutic approach for complex metabolic disorders like diabetes and associated diseases, wher Furthermore, obesity is associated with the development of cardiovascular risk factors like increased insulin resistance and type 2 diabetes mellitus T2DM , hypertension and dyslipidemia However, the specific skills required to manage insulin pumps may hamper social integration as much as the fear of severe hypoglycemia using conventional therapy The overall incidence of recurrent DKA episodes is estimated as 8 per patient years.

The catalytic activity of TPI can induce permanent changes in its structure and a decline in activity. Under conditions of high glycolytic flux, insufficient TPI activity may eventually cause the accumulation of dihydroxyacetone phosphate TPI substrate which spontaneously decomp Hypoglycemia, however, is a major safety concern that is associated with the use of SUs, because it impairs a patient's quality of life and can become li Prospective studies on secondary OHA failure have not been done in Nigeria.

The aim of this study was to determine the prevalence and risk factors associated with development of secondary failure of OHA among T2DM subjects We used patients' zip codes to link to US census data to get socioeconomic status information. HbA1c variability was Despite anecdotal reports of adverse cardiovascular and hemodynamic effects of energy drink consumption there has been very little scientific research conducted on this important topic.

Furthermore, the limited research available has not yielded consistent results. This study tested the hypothesis that consumption of a commercially available energy The estimated prevalence of diabetes nowad The necessity of blood glucose control in those patients with low variability and avoidance of hypoglycemic episodes is well-known. Yet, there is still only marginal literature about the optimal therapy of hyperglycemia in non critically ill hospitalized patients using tools of modern electronic patients charts.

Objectives:The present study aimed to investigate the feasibility Even if suspected today to contribute in a lipid rafts transfer system, from endoplasmic reticulum to mitochondria, the precise function of ATAD3 is still unknown. However, ATAD3 has been previously shown to exhibits in vitro anti-proliferative and chemo resistant properties and to be a positive marker of different t Methods:Retrospective review of routine electronic medical records of patients treated for diabetes between October 1, and September 30, was conducted.

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Baseline demographic and clinical characteristics are described. Outcomes of HbA1c values, loss to follow On the other hand, diabetes mellitus DM is the most famous chronic and metabolic disease which may lead to many cardiac, renal and infectious complications. Therefore regular blood sugar control is extremely important in diabetic man We assessed the effect of a shorter course of intensive insulin therapy on insulin sensitivity in people with T2DM.

Fifteen poorly controlled subjects with severe hyperglycemia were hospitalized and treated with intensive insulin therapy for 7 days. The short insulin to Systematic sampling method was used to recruit study subjects. The PHQ-9 questionnaire was used to assess for co-morbid depression. Socio-demographic and clinical details were obtained both from the subjects and their medical records.

Physical examination was done, including blood pressure and BMI de Type 2 diabetes patients attending the outpatient clinic of the UMCU were approached to participate in a nationwide biobank study. In the UMCU, patients were also approached to participate in a local add-on study this study , which required separate consent Human mitochondrial mt DNA haplogroups are maternally inherited ancient polymorphisms representing different geographic origins of populations.

Haplogroups are defined by accumulations of single nucleotide polymorphisms SNPs , some of which cause c An observational, prospective, longitudinal, comparative study was carried out. Patient selection was carried out through consecutive non-probability sampling Additionally, we intend to study the sl The aim of this study was to assess the economic burden of DM management and its complications in Beirut through comparing the hospitalization cost for patients with DM to that of patients not suffering from DM Estimates by the International Diabetes Federation indicate that million people have diabetes, and that this figure is expected to rise to million by with an additional million cases currently undiagnosed.

Individuals with T2DM are at a significantly higher risk of co-morbidities particularly cardiovascular disea However in insulin resistant type 2 diabetes, the improvement in glycaemic control with insulin, is not without side effects, especially weight gain and hypoglycaemia. Many retrospective or case-control studies of insulin treatment have reported a higher prevalence of CVD in insulin-treated patients. Hatanaka, Hiroyuki Kobayashi, Chikara Shimizu, and Tatsuya Atsumi Article Type: Case Report First Published: November 05, Although the excessive secretion of GH leads to insulin resistance enhancement, the involvement of a silent somatotroph adenoma in abnormal glucose tolerance has not been elucidated.

Clinical Perspectives on Obesity Treatment: Challenges, Gaps, and Promising Opportunities

A 50 - year-old man was admitted with a headache and bitemporal hemianopia caused by a pituitary macroadenoma. He had no physical signs and symptoms of acromegaly nor hypopituitarism, and his base-line serum levels of GH and insulin - like growth factor-1 IGF-1 wer Franco Contaldo, Maurizio Marra, Lidia Santarpia and Fabrizio Pasanisi Article Type: Hypothesis First Published: October 28, We selected, from our database of obese outpatients, 90 young severely obese subjects 60 females, 30 males in a stable body weight since at least 6 months, age range 20 - 30 years, who underwent measurements of resting energy expenditure REE by indirect calorimetry VMax Sensor Medics and body composition was evaluated by bioelectrical impedance BIA.

Methods: Using a purposive sampling scheme, 29 participants 26 women and 3 men, mean age 48 years and average length of residency of 22 years in Canada participated in this study. J Diabetes Complications. Systematic literature review of the health economic implications of early detection by screening populations at risk for type 2 diabetes. Current medical research and opinion. American Diabetes Association. Promoting health and reducing disparities in populations.